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March 1971


Author Affiliations

Department of Dermatology University of Miami, School of Medicine Miami, Fla 33136

Arch Dermatol. 1971;103(3):343. doi:10.1001/archderm.1971.04000150113027

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To the Editor.—  A recent review article in the Archives, "Drug Reactions to the Sulfones" (102:220-223, 1970), contains an error. The authors refer to the "two free amide groups" and "substitution on the amide groups" of diaminodyphenyl sulfone. An amide group is a derivative of ammonia that is formed by substituting an acyl group for an ammonia hydrogen; for example, the peptide bond contains an amide group. The nitrogen groups on diaminodyphenyl sulfone are primary amines and not amides.

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