A dominantly inherited disorder has affected ten members of a family group. At present we recognize the following categories of clinical involvement: (1) vesicopustule formation which remains confined to the hands and feet (this process commences at from 1 to 3 months of age and resolves in late childhood); (2) widespread eczematous dermatitis somewhat resembling atopic eczema which starts between the ages of 3 and 6 months and completely resolves by 5 years of age; (3) the gradual appearance of a diffuse poikiloderma with striate and reticulate atrophy which spares only the face, scalp, and ears (the poikiloderma persists into adult life); and (4) the development of keratotic papules on the hands, feet, elbows, and knees, which first appear at varying times prior to 5 years of age and persist indefinitely.
Weary PE, Manley WF, Graham GF. Hereditary Acrokeratotic Poikiloderma. Arch Dermatol. 1971;103(4):409–422. doi:10.1001/archderm.1971.04000160059010
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: