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May 1971

Intensified Contact Sensitization to Benzyl Salicylate: Phototoxic Effects of Topical Psoralen Therapy

Author Affiliations


From the Division of Dermatology, University of Colorado Medical Center, Denver.

Arch Dermatol. 1971;103(5):497-500. doi:10.1001/archderm.1971.04000170031007

Benzyl salicylate (BS), a weak contact sensitizer, caused severe pruritus in six of 15 patients who applied it in a trioxsalen lotion. Delayed hypersensitivity to BS was enhanced by the phototoxic effects of methoxsalen. Only one of 14 control patients reacted to the BS.