To the Editor.—
The immunologic approach to treatment of cancer and precancerous lesions is relatively new. It consists of enhancing the cellular immune mechanisms of the host in order to obtain rejection of the neoplasm. In recent years nonspecific agents have been used to stimulate the host's immune system. BCG vaccine has been used with limited success in acute leukemia1 and in malignant melanoma (Medical Tribune 1, 1970). Ratner and associates have used 2-4-dinitrochlorobenzene in mycosis fungoides with some success,2 although recurrence of lesions or development of new ones was almost always seen within months.3 In a more recent communication4 Van Scott and Winters reported complete remissions of from two to nine months in 11 of 14 patients with plaque stage of mycosis fungoides and in 3 of 4 patients with generalized erythema who had been treated with mechlorethamine hydrochloride (nitrogen mustard) topically. The best results
Mandrea E. SUCCESSFUL TREATMENT OF PARAPSORIASIS EN PLAQUES WITH 2-4-DINITROCHLOROBENZENE. Arch Dermatol. 1971;103(5):560–561. doi:10.1001/archderm.1971.04000170094021
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