Reticulum cell sarcoma in a patient presented an initial picture of mycosis fungoides d'emblee. Atypical cells with indented convoluted nuclei similar to those described by Lutzner were demonstrated electron microscopically in skin tumors. On light microscopy, 1μ epoxy-embedded specimens from the lymph node and several internal organs involved by the process revealed similar cells with these indented nuclei. It is felt that the "Lutzner cell" is not a specific indicator of mycosis fungoides, but may be found in other types of lymphomas. Whether it can occur in completely different dermatoses or is a characteristic cell that is distinctive for the lymphomas as a group requires further investigation.
Petrozzi JW, Raque CJ, Goldschmidt H. Malignant Lymphoma, Reticulum Cell Type: Ultrastructural and Cytological Demonstration of Lutzner Cells. Arch Dermatol. 1971;104(1):38–44. doi:10.1001/archderm.1971.04000190040006
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.