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July 1971

Malignant Lymphoma, Reticulum Cell TypeUltrastructural and Cytological Demonstration of Lutzner Cells

Arch Dermatol. 1971;104(1):38-44. doi:10.1001/archderm.1971.04000190040006

Reticulum cell sarcoma in a patient presented an initial picture of mycosis fungoides d'emblee. Atypical cells with indented convoluted nuclei similar to those described by Lutzner were demonstrated electron microscopically in skin tumors. On light microscopy, 1μ epoxy-embedded specimens from the lymph node and several internal organs involved by the process revealed similar cells with these indented nuclei. It is felt that the "Lutzner cell" is not a specific indicator of mycosis fungoides, but may be found in other types of lymphomas. Whether it can occur in completely different dermatoses or is a characteristic cell that is distinctive for the lymphomas as a group requires further investigation.