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July 1971

Local Changes at the Site of Pentazocine Injection

Author Affiliations

Iowa City; Ann Arbor, Mich

From the Department of Dermatology, University of Iowa Hospitals, Iowa City (Drs. Schlicher and Zuehlke), and the Department of Dermatology, University of Michigan, Ann Arbor (Dr. Lynch).

Arch Dermatol. 1971;104(1):90-91. doi:10.1001/archderm.1971.04000190092016

Soft tissue induration occurred following chronic pentazocine injection in three patients. Inflammatory nodules, cutaneous depression, and ulceration also developed in one or more of these three patients. However, in some cases, there may be incomplete absorption of the solution and precipitation due to the slightly alkaline pH of extracellular fluid. The precipitated crystals may initiate a chronic inflammatory response.

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