To the Editor.—
Keratosis (keratoderma) of the palms and soles is one of the most complex problems presented to the dermatologist and geneticist.1-4 A classification of these disorders is presented here (Table). Pseudogenetic causes, such as arsenic-contaminated family water supply must be ruled out. In some cases, biopsy is helpful in differentiating these conditions, ie, bullous congenital icthyosiform erythroderma and basal cell nevus syndrome, the latter which may at times reveal basal cell hamartomas of the palms. Often biopsy results are disappointing because of unnecessary caution resulting in a failure to obtain an adequate specimen. For the most part the results of the biopsy then are unrewarding.6This classification is an essential step in the classification of this heterogenous group of disorders. Certain entities that are not well established have been excluded and others will undoubtably be added. The authors, one or both, have studied all of the
Reed WB, Porter PS. KERATOSIS. Arch Dermatol. 1971;104(1):99–100. doi:10.1001/archderm.1971.04000190101022
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