After a considerable amount of animal work with zinc in wound healing, Pories et al1 captured the imagination of optimistic clinicians with the publication of his studies on the acceleration of wound healing in man with zinc sulphate given orally. Ten healthy servicemen with clean surgical wounds resulting from pilonidal sinus excision were given zinc sulphate orally in doses of 220 mg three times daily. Wound healing was measured objectively by calculating the volume of the resulting wounds and determining the healing rate as the wound volume decreased. A similar group of ten patients served as controls. The time necessary to produce healing, defined as complete reepithelialization, was almost twice as great in control patients as in patients given zinc. The healing rate was nearly three times greater in treated patients. The significance of this increased healing rate is uncertain because the average volume before therapy of the wounds
Fulghum DD. Zinc Zealots and Zetetics. Arch Dermatol. 1971;104(2):210–211. doi:10.1001/archderm.1971.04000200098018
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