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August 1971


Author Affiliations

Departments of Dermatology and Pathology University of Miami Miami, Fla

2 W 87th St New York

Arch Dermatol. 1971;104(2):219. doi:10.1001/archderm.1971.04000200107022

To the Editor.—  In the innocuous cutaneous nodule, commonly called dermatofibroma, may be hidden secrets about the influence of mesenchyme upon epithelium. Epidermal hyperplasia of various kinds, including basal cell carcinoma-like proliferation, is a well recognized concomitant of this primary dermal process. Recently, the occurrence of focal keratosis follicularis overlying dermatofibroma was reported.1 We call attention to a second similar case, a solitary lesion on the leg of a 44-year-old white woman who had no other evidence of Darier's disease. This phenomenon, keratosis follicularis overlying dermatofibroma (Fig 1 and 2), may be one clue to the riddle of mesenchymal-epithelial interaction and to the dynamics of Darier's disease.