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August 1971


Author Affiliations

Department of Dermatology Baylor College of Medicine 1200 Moursund Ave Houston 77025

Arch Dermatol. 1971;104(2):221-222. doi:10.1001/archderm.1971.04000200109026

To the Editor.—  In recent years a number of congenital disorders of fibrinogen have been reported.1 Most patients with these abnormalities either have no symptoms referable to their dysfibrinogenemia or have bleeding tendencies of varying severity. Recently, Beck et al described an inherited abnormality of fibrinogen which resulted in both a mild hemorrhagic tendency and predisposition toward venous thrombosis.2 They called the abnormal fibrinogen responsible for this syndrome "fibrinogen Baltimore." At the Ben Taub General Hospital Dermatology Clinic we recently saw a patient with stasis dermatitis and ulcers secondary to venous thrombosis who is a member of the family originally described by Beck and his colleagues with this unusual fibrinogen variant.

Report of a Case.—  Our patient, a 72-year-old white man, had severe thrombophlebitis involving the left leg in 1958. Since that time he has had persistent swelling of the left foot and lower portion of the left