The daily topical application of 0.1% tretinoin (vitamin A acid) solution was very effective in eliminating senile comedones from the faces of four middle-aged men.
Kligman AM, Plewig G, Mills OH. Topically Applied Tretinoin for Senile (Solar) Comedones. Arch Dermatol. 1971;104(4):420–421. doi:10.1001/archderm.1971.04000220078015
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