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October 1971


Author Affiliations

Director of Medical Affairs E. R. Squibb and Sons Limited, Regal House, Twickenham, Middlesex, England

Arch Dermatol. 1971;104(4):437-438. doi:10.1001/archderm.1971.04000220095025

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To the Editor.—  I was interested to read Dr. Coskey's letter in the Archives (103:228, 1971) and the possible case of contact dermatitis due to nystatin.The materials used for patch testing were thimerosal (Merthiolate), Mycolog cream, 0.01% triamcinolone acetonide in Velvachol, 0.025% gramicidin in Velvachol (cream base for Mycolog), 1% ethylenediamine aqueous solution, and 100,000 units of nystatin per gram of Velvachol.Dr. Coskey found that patch tests were markedly positive to Mycolog, ethylenediamine, the cream base for Mycolog (Velvachol), and nystatin. He then makes a statement that this is the second case to be reported of contact dermatitis from nystatin.Dr. Coskey's letter does not indicate that he patch tested to nystatin on its own but to nystatin in Velvachol. As he showed a positive patch test to the Velvachol, I cannot understand why he claims the patient had a sensitivity to nystatin. Furthermore, the patient should

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