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November 1971

Chromomycosis: Treatment With Thiabendazole

Author Affiliations

Durban, South Africa

From the Department of Dermatology, King Edward VIII Hospital and University of Natal, Durban, South Africa.

Arch Dermatol. 1971;104(5):476-485. doi:10.1001/archderm.1971.04000230018003

Fourteen patients with chromomycosis have been treated orally with thiabendazole, either alone or in combination with surgery. Apparent cures have been obtained in five according to the criteria considered mandatory. The drug is well tolerated in the majority of cases with only minor symptoms of nausea and headache occurring at higher dosage levels. A hypersensitivity reaction, not previously recorded, developed in several patients, manifested by elevated serum bilirubin and transaminase values. The need for regular laboratory investigations is stressed. The problems and consequences of surgical intervention, including biopsies, may be due to the role of trauma in reactivating the infection. It is concluded that, at present, thiabendazole warrants a definite place in the treatment of chromomycosis.