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January 1972

Pyoderma Gangrenosum, Altered Delayed Hypersensitivity, and Polyarthritis

Author Affiliations

Cambridge, England; Boston; USN, Chelsea, Mass

From the Department of Dermatology, Massachusetts General Hospital (Drs. Lazarus and Goldsmith), and the Department of Medicine, Robert Breck Brigham Hospital (Drs. Rocklin and David), Harvard Medical School, Boston; the Medical Service, Lemuel Shattuck Hospital, Tufts University School of Medicine, Department of Public Health, Boston (Drs. Pinals and Buisseret); and US Naval Hospital, Chelsea, Mass (Dr. Draper). Dr. Lazarus is now with Strangeways Research Laboratories, Cambridge, England.

Arch Dermatol. 1972;105(1):46-51. doi:10.1001/archderm.1972.01620040018003

Four patients with pyoderma gangrenosum were found to have an abnormality of delayed hypersensitivity that was characterized by cutaneous anergy and dissociation between macrophage inhibitory factor production and blastogenic response in vitro. Three of these four patients had a rheumatoid-like polyarthritis. One patient responded to conservative therapy but three required high doses of corticosteroids for healing of the ulcers.