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February 1972

A New Approach to the Reduction of Sebum Secretion

Arch Dermatol. 1972;105(2):294. doi:10.1001/archderm.1972.01620050092023

To the Editor.—  The report by Harville and Appenzeller in the Archives (103:492, 1971) of a reduction in sebum secretion in four out of nine parkinsonian patients taking levodopa must surely be viewed with some reservations.Patients 1, 2, and 6 seem to show a decrease in sebum excretion rate which is probably significant. Patients 3 and 8 showed widely fluctuating levels of sebum excretion rate which in our experience most often result from defects in the collection method. No conclusion can be drawn from patient 4 who was studied for too short a period and one base line sample was lost. Patients 5, 7, and 9 show an increase in sebum excretion rate with therapy.Thus at best three out of the nine subjects show a significant decrease in sebum excretion rate but conversly six out of nine patients failed to show a decrease in sebum excretion rate

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