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April 1972

Subepidermal Calcified Nodules

Author Affiliations


From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Arch Dermatol. 1972;105(4):593-597. doi:10.1001/archderm.1972.01620070065025

Subepidermal cutaneous calculi usually occur as solitary lesions, and since their recognition as a definite entity with a characteristic histopathology, reported cases have not been associated with biochemical abnormalities, other dermatologic disorders, or with systemic illness. The occurrence of numerous subepidermal cutaneous nodules in a young Negro boy with ichthyosis, serious liver disease, and an elevated sweat calcium level raised the possibility that dermatologic and systemic abnormalities may play a role in the pathogenesis of this condition. Winer's concept that the tumor is a calcified hamartoma of sweat duct origin is supported by demonstration of similar histologic changes in calcified syringomas and by the elevated sweat calcium level.