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April 1972

Tetracycline Therapy in Acne Vulgaris

Arch Dermatol. 1972;105(4):608. doi:10.1001/archderm.1972.01620070078032

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To the Editor.—  Tetracycline is well established as a useful treatment of acne vulgaris. The doses usually administered vary from 250 mg to 1,000 mg/day. Often these standard doses of tetracycline are ineffective in nodulocystic and conglobate acne and systemic steroid therapy may be required.For the past year we have prescribed tetracycline in doses ranging from 1.5- to 3.0-gm/day to selected patients with nodulocystic and conglobate acne. All these patients have had previous antibiotic therapy in conventional doses and other forms of conventional therapy. Eighty cases have been followed for three months or longer. The results to date are encouraging; many patients have shown good to excellent improvement. The only side effect observed to date has been phototoxic effects in two patients.These uncontrolled results indicate the need for a statistically controlled, clinical study, as well as assays of sebum production and its composition. Cutaneous tetracycline levels in patients

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