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May 1972

Antiepithelial Antibodies in Prostatic Cancer

Arch Dermatol. 1972;105(5):759. doi:10.1001/archderm.1972.01620080081024

To the Editor.—  Preliminary screening of serum from patients with clinical stages of carcinoma of the prostate (CaP) was done; an attempt was made to delineate possible tissue-specificity of recently described immunohistologic localization of IgG antibodies to the cytoplasmic membrane (CM) of secretory epithelial cells of monkey prostatic tissue.1 Antibody to the intercellular (IC) areas of stratified squamous epithelium of mouse esophagus has been observed in the serum of 38% (five of 13) of the patients previously shown to contain CM antibodies to prostatic tissue. Serum from three other patients with CaP, negative (< 1:10) for CM antibodies on prostate tissue, also possessed IC antibodies on esophagus tissue. Indirect immunofluorescent (IF) staining titers of IC antibodies in these CaP patients, with or without CM antibodies, ranged from ratios of 1:10 to 1:60 (highest serum dilution tested in this preliminary screening). Six of the eight still had positive reactions at