The McKenzie and Stoughton (1962) method for evaluating the vasoconstrictive properties of corticosteroids has been modified as follows: test compounds are incorporated into coded, glassine backed 1-cm squares of thin absorbent paper which are applied to forearm surfaces at 5-mm intervals according to a predetermined plan. Results are (1) improved experimental design, (2) avoidance of error inherent in applying alcoholic solutions directly to convex skin surfaces, (3) increased numbers of test sites per subject, (4) increased ease and accuracy of recording reactions and (5) decreased test subject discomfort during the test. Four new difluoroprednisolone diesters were found by this method to be significantly more active than the reference standard betamethasone 17-valerate.
Falconi G, Rossi GL. Paper-Patch Test for Evaluating Vasoconstrictive Activity of Corticosteroids. Arch Dermatol. 1972;105(6):856–858. doi:10.1001/archderm.1972.01620090028006
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