[Skip to Content]
[Skip to Content Landing]
July 1972

Prostaglandins in Cutaneous Biology

Arch Dermatol. 1972;106(1):101-107. doi:10.1001/archderm.1972.01620100083025

Prostaglandins are present in numerous mammalian tissues and have widespread biological actions. Fourteen members of four series (E, F, A, and B) have been identified. The E and, to a lesser degree, the F compounds are dilators of the cutaneous vasculature with long-lasting (up to ten hours) responses. They may play a role in cutaneous inflammation, both by releasing histamine and independent of histamine, and have been isolated from perfusates of contact dermatitis and ultraviolet light-induced inflammation. Prostaglandins are inhibitors of gastric secretion, lipolysis, and platelet aggregation, and are also implicated in nerve transmission, human reproduction, muscular contractility, and ion and water transport. Many of their effects seem to be mediated via the adenyl cyclase-cyclic adenosine monophosphate system. Whether they function as hormonal regulators is still not resolved.