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July 1972

Use of Cytarabine for Herpesvirus Infections

Arch Dermatol. 1972;106(1):130. doi:10.1001/archderm.1972.01620100104036

To the Editor.—  Cytarabine (Cytosar), an anti-cancer drug, administered for herpesvirus infection appears to be a new, useful therapy for simplex and zoster-varicella.1 As indicated in the article, the immunosuppressive and cytotoxic qualities of this drug will require careful monitoring. I would like to report similar beneficial effects with griseofulvin (a safer drug, although any drug can cause untoward reaction) which have rarely been encountered in the patients I have treated for fungal infections with the usual doses and for zoster-varicella and herpes simplex with the high doses.Due to the fact that viral studies were not possible and other laboratory work was not done in an office practice, a formal report has not been made. Randazzo and Giardina,2 reported complete healing of zoster with no residual neuralgia in 14 of 18 cases treated with griseofulvin at a dosage of 250 to 500 mg for two infants and

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