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August 1972

Acne Vulgaris: Oral Therapy With Tetracycline and Topical Therapy With Vitamin A

Author Affiliations


From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Arch Dermatol. 1972;106(2):200-203. doi:10.1001/archderm.1972.01620110036009

Over an eight-week period, three treatments for moderately severe acne were compared in groups of adolescents: (1) 0.05% daily vitamin A acid (retinoic acid) alone; (2) demeclocycline hydrochloride alone, 600 mg a day for the first three weeks, 300 mg thereafter; (3) a combination of the two. In addition to clinical assessment, subjects in each group were studied with regard to the relationship of free fatty acids (FFA) to the density of Corynebacterium acnes.

The combination therapy produced the swiftest and greatest effect on all three factors: therapeutic benefit, decreased FFA, and reduction in the anaerobic microflora.

It was postulated that vitamin A potentiated the effect of demeclocycline by bringing about an increased tissue concentration of the antibiotic.

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