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October 1972

Nonfatal Wiskott-Aldrich Syndrome in a 15-Year-Old Boy

Arch Dermatol. 1972;106(4):541-542. doi:10.1001/archderm.1972.01620130069016

An unusual case of Wiskott-Aldrich syndrome is reported. The patient has now reached an age of 15 years. To my knowledge, he is the oldest living patient suffering from this syndrome. He still has diminished resistance to infections, thrombocytopenia, and atopic dermatitis. The patient has blood type O, his titer of isoagglutinin A is significantly reduced, and isoagglutinin B was not demonstrable. Furthermore, an increased value of IgE was registered. The displacements in IgM and IgA were the same as reported by other authors. Serum-type and tissue-type were also examined. Reaction to prostaglandin E1 injected intracutaneously was normal, but the same administration of histamine resulted in a blanching that is usually seen in patients suffering from atopic dermatitis.