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December 1972

Keratosis Follicularis (Darier's Disease): Response to Simultaneous Administration of Vitamins A and E

Author Affiliations

Los Angeles

From the Department of Dermatology, University of California at Los Angeles, the Center for the Health Sciences (Dr. Ayres) and the Department of Dermatology and Syphilology, University of Southern California School of Medicine (Dr. Mihan), Los Angeles.

Arch Dermatol. 1972;106(6):909-910. doi:10.1001/archderm.1972.01620150091028

A young man with a severe eruption of keratosis follicularis (Darier's disease) of long duration had failed to respond to continuous administration of vitamin A in large doses over a five year period. Seven months after adding vitamin E in a dose of 1,200 international units (IU) daily and continuing vitamin A, the eruption had improved approximately 75%.

It is speculated that the striking improvement in this recalcitrant case was due to a synergistic action of vitamin E with vitamin A, previously demonstrated experimentally. If these results can be duplicated, it would suggest the advisability of the combined administration of these vitamins in those conditions where vitamin A is indicated, thus facilitating its utilization and lessening the danger of hypervitaminosis A by reducing the amounts required for a therapeutic effect.