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March 1973

Pemphigus Vulgaris Treated With Cyclophosphamide

Author Affiliations

Brooklyn, NY

Arch Dermatol. 1973;107(3):467-468. doi:10.1001/archderm.1973.01620180105043

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To the Editor.—  Krain et al (Arch Dermatol 106:657-661, 1972) reported five cases of pemphigus vulgaris treated with cyclophosphamide. In their references, they cited to two other cases that had been similarly treated. These authors make the point that, since so few cases have been reported, the proper dosage range remains to be establishedIn view of this, we deemed it appropriate to report on one more case of pemphigus vulgaris treated with cyclophosphamide.

Report of a Case  A 50-year-old woman was first seen in March 1968 because of a generalized bullous eruption. "Sores" in the mouth had first appeared in 1967. On examination, intact and ruptured bullae were seen scattered over the entire body. Lesions in the mouth and nose were noted. Nikolski's sign was positive. A biopsy confirmed the diagnosis of pemphigus vulgaris.The patient was treated orally with prednisone in varying dosages up to 60 mg/day, with adequate

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