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April 1973

Verrucae Vulgaris Rejection: A Preliminary Study of Contact Dermatitis and Cellular Immunity Response

Author Affiliations

USA; USA; Fort Sam Houston, Tex

From the Department of Dermatology (Drs. Greenberg and Smith), and the Allergy-Immunology Service (Dr. Katz), Brooke General Hospital, Fort Sam Houston, Tex. Dr. Katz is now at UCLA School of Medicine, Los Angeles.

Arch Dermatol. 1973;107(4):580-582. doi:10.1001/archderm.1973.01620190056013

Clinical and histologic correlations were performed on five adult patients with verrucae vulgaris lesions and on four normal adult volunteers without verrucae after induction of irritant contact dermatitis and subsequent allergic contact immune response to 1-nitro-2,4-dichlorobenzene (DNCB). Four of the five patients with warts and all of the control patients developed normal delayed cutaneous hypersensitivity (DCH) reactions. The four patients with verrucae vulgaris, with induced DCH responses, had disappearance of the warts after topical challenge by DNCB. After several weeks, two of these patients experienced complete disappearance of all nontreated warts, as well.

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