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May 1973

Intertriginous Xanthomata in Type 2 Hyperbetalipoproteinemia

Author Affiliations


From the Department of Dermatology, Children's Hospital Medical Center, and Massachusetts General Hospital, Harvard Medical School, Boston. Dr. Goldsmith is presently at the Department of Medicine, Duke University Medical Center, Durham, NC.

Arch Dermatol. 1973;107(5):761-762. doi:10.1001/archderm.1973.01620200075022

Two children with type 2 hyperbetalipoproteinemia were noted to have a previously undescribed type of intertriginous xanthoma (ITX). Family members of one child had clinical evidence of type 2 disease. Both patients demonstrated a different spectrum of xanthoma types, and review of reported cases of familial hyperbetalipoproteinemia revealed a similar variation in clinical expression. Recognition of distinctive phenotypic features, such as ITX, may lead to the differentiation of discrete subgroups among patients with type 2 hyperbetalipoproteinemia.

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