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Advances in our knowledge of immunology have been made possible both by observations at the bench and at the bedside. Many so-called experiments of nature have prompted laboratory investigators to perform experiments that they would not otherwise have performed had not the patient with the peculiar problem presented himself to a curious physician. At the present time, because of the vast increase in information in immunology that is relevant to clinical medicine, there is a need for well-conceived and well-written reviews of selected topics. In this, the first volume of Progress in Clinical Immunology, the editor, Robert S. Schwartz, and the contributors have set themselves the task of providing informative and well-written reviews of several important topics in clinical immunology. Specifically, the question of the etiologic agents in immune complex diseases is reviewed, and this is followed by a chapter on viruslike structures in systemic lupus erythematosus. The relationship of