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Original Contribution
August 1973

Topical Steroid-Antibiotic Combinations: Assay of Use in Experimentally Induced Human Infections

Author Affiliations

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia. Dr. Marples is now at the Central Public Health Laboratory, Colindale Ave, London. Dr. Rebora is now at the Clinica Dermatologica Universita, Genoa, Italy.

Arch Dermatol. 1973;108(2):237-240. doi:10.1001/archderm.1973.01620230037013

Whether antibiotics should be combined with topical steroids in the treatment of chronic dermatoses is a question that is extraordinarily difficult to answer. The alternative proposed in this study is appraisal of efficacy in experimental human infection with Staphylococcus aureus and Candida albicans. With a broad spectrum steroid-antibiotic combination containing triamcinolone acetonide, neomycin gramicidin, and nystatin, it was possible to show that omission of any one component decreased the effectiveness of the mixture. The steroid by itself suppressed the experimental lesion without influencing the multiplication of the pathogen.

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