With the rapid development of laser technology, higher output lasers and new lasers continue to be made. Lasers now extend from the ultraviolet far into the infrared. There is now considerable interest and controversy about x-ray lasers. The skin continues to be an easily available and controlled clinical test model for initial investigations of the effect of these lasers on man. Such studies help also in the development of safety programs for the use of lasers and for clinical applications. Brief mention will be made of the current applications of the laser for diagnosis and treatment in dermatology.