[Skip to Navigation]
September 1973

Hypersensitivity to Drugs

Author Affiliations

Rochester, Minn

Arch Dermatol. 1973;108(3):442. doi:10.1001/archderm.1973.01620240082038

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


In the early part of this century, Landsteiner showed that chemicals of small molecular weight could function as antigens when coupled to protein carriers of large molecular weight. He correctly anticipated the subsequent course of research on the problems of drug allergy, which in his day were comparatively minor. In this text, a comprehensive review of the problem of hypersensitivity to drugs is taken. Numerous aspects of drug allergy, beginning with the affinity of the various drugs to proteins, the reactivity in terms of formation of covalent bonds with proteins, the immune response, and the various aspects of drug hypersensitivity in terms of organ involvement, are discussed in considerable detail. The book is divided into two sections that deal with the principles of drug hypersensitivity including most of the subjects just mentioned (chapters 1 through 7) with the reactions in specific organs and organ systems caused by drug hypersensitivity.

First Page Preview View Large
First page PDF preview
First page PDF preview
Add or change institution