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November 1973


Arch Dermatol. 1973;108(5):733. doi:10.1001/archderm.1973.01620260073036

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Erythroplasia of Queyrat. Presented by Anthony N. Domonkos, MD.  An uncircumcised 55-year-old man complained of irritation and redness of the glans penis of 15 years' duration. Topically applied ointments, especially a mixture of neomycin sulfate and methylprednisolone (Neo-Medrol), controlled the irritation but did not cure it. The patient had a history of rheumatic heart disease for which he took penicillin daily. He also took quinidine sulfate and aspirin.Examination revealed sharply circumscribed erythematous patches on the glans and prepuce, with central oozing. A biopsy specimen taken in November 1971 was interpreted as erythroplasia of Queyrat. Initial cultures for fungi were negative.Treatment was started with 5% fluorouracil cream applied twice daily for twoweek intervals on two separate occasions: November 1971 and January 1972. This resulted in markedly eczematous reactions followed by the development of a pseudomembrane, which healed with complete clearing of the lesion. Several recurrences were treated with liquid

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