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December 1973

Increased Frequency of HL-A10 in Pemphigus Vulgaris

Author Affiliations

Los Angeles

From the departments of medicine (Division of Dermatology), biomathematics, and surgery, University of California, Los Angeles School of Medicine, Los Angeles. Dr. Krain is now Executive Coordinator, National Clinical Cooperative Melanoma Project, Harvard Medical School, Massachusetts General Hospital, Boston.

Arch Dermatol. 1973;108(6):803-805. doi:10.1001/archderm.1973.01620270029007

In order to determine if there was an association of pemphigus vulgaris and any antigenic specificity of the HL-A system, 43 unrelated white patients with pemphigus vulgaris were typed for HL-A by the microdroplet lymphocyte cytotoxicity test. HL-A10 was present in 17 of 28 unrelated Jewish patients with pemphigus vulgaris (60.7%) as compared to 19 of 94 Jewish control patients (20.2%) (P<.0001). Among female patients, the occurrence of HL-A10 was 71% and among male patients, 45%. HL-A10 was elevated but not significantly associated with pemphigus vulgaris in non-Jewish whites. No significant associations were noted for other HL-A specificities. A pemphigus susceptibility gene linked to HL-A is postulated.

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