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January 1974

Vitamin E Treatment of Epidermolysis Bullosa: Changes in Tissue Collagenase Levels

Author Affiliations


From the departments of dermatology (Drs. Michaelson, Schmidt, and Duncan) and biochemistry (Dr. Dresden), Baylor College of Medicine, Houston.

Arch Dermatol. 1974;109(1):67-69. doi:10.1001/archderm.1974.01630010043010

Three patients with dystrophic epidermolysis bullosa (DEB) were treated with vitamin E, with the result that bullae formation ceased. Measurement of collagenase activity in the blister areas revealed a reversion to normal collagenase activity after 30 days of vitamin E therapy. These findings tend to support the theory that DEB is influenced by the increase in the level of skin collagenase, and the increased collagenase activity directly influences blister formation.

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