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January 1974

Localized Epidermolysis Bullosa: Report of Two Cases and Evaluation of Therapy With Glutaraldehyde

Author Affiliations


From the Division of Dermatology, Ottawa General Hospital and the University of Ottawa, Ottawa.

Arch Dermatol. 1974;109(1):70-72. doi:10.1001/archderm.1974.01630010046011

In two patients with localized epidermolysis bullosa (recurrent bullous eruption of the hands and feet or Weber-Cockayne syndrome), experimentally induced blisters were studied histopathologically. The blisters showed cleft formation in the suprabasal layer of the epidermis. Therapy with topically applied 10% glutaraldehyde was found to be beneficial, but the irritant and skin-sensitizing side-effects of this chemical proved to be a limiting factor in its use.

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