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January 1974

Unsuccessful Fluorouracil Treatment of Psoriasis

Arch Dermatol. 1974;109(1):102. doi:10.1001/archderm.1974.01630010074034

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To the Editor.—  In a letter in the July issue of the Archives (108:135, 1973), Drs. Barrett and Sayers reported a case of unsuccessful fluorouracil treatment of recalcitrant pustular psoriasis.I treated three patients who had severe generalized psoriasis; two of these patients had erythroderma psoriaticum. Treatment consisted of intravenous administration of fluorouracil at a dosage of 500 mg to 1,000 mg/day for five successive days. This method of treatment was a complete failure. It is possible that a different dose schedule might have been successful.

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