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February 1974

Pemphigus-like Antibodies in Cicatricial Pemphigoid

Author Affiliations

San Francisco

From the Department of Dermatology, University of California School of Medicine, San Francisco.

Arch Dermatol. 1974;109(2):235-238. doi:10.1001/archderm.1974.01630020047012

Two patients with cicatricial pemphigoid had antibodies in their sera directed to the intercellular area of epithelium. Their disease began with mucosal ulcerations and conjunctival lesions, which resulted in scarring. Direct immunofluorescence revealed bound IgG at the basement membrane zone of involved tissue of the eyes and mouth, but ultraviolet light testing failed to produce new lesions in normal-appearing skin. The finding of circulating intercellular antibodies in cicatricial pemphigold could add confusion to its diagnosis. The relationship of this finding to pemphigus, bullous pemphigoid and to skin conditions producing pemphigus-like antibodies is considered.

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