A 51-year-old man with idiopathic hypoparathyroidism that had been untreated for more than nine years developed erythematous lesions with erosion and lamellar scales resembling exfoliative dermatitis. Depilation of scalp and axillary hair, nail changes, and cataracts were also noted. These skin changes appeared almost simultaneously with severe reduction of the serum calcium level. Treatment with ergocalciferol and gluconate calcium greatly improved these dermal lesions as well as other hypocalcemic symptoms. Normalization of the serum calcium level followed.
It is likely that exfoliative dermatitis-like lesions may occur as skin manifestations of idiopathic hypoparathyroidism, although such manifestations are extremely rare.
Hirano K, Ishibashi A, Yoshino Y. Cutaneous Manifestations in Idiopathic Hypoparathyroidism. Arch Dermatol. 1974;109(2):242–244. doi:10.1001/archderm.1974.01630020054014
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.