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February 1974

Pseudomonas Infections

Author Affiliations

Fontana, Calif

Arch Dermatol. 1974;109(2):261-262. doi:10.1001/archderm.1974.01630020069021

To the Editor.—  An increased incidence of Pseudomonas infections has been reported by Ammonette and Rosenberg1 and Tomoka et al.2 More serious infections are nosocomial, particularly in newborn nurseries.Ammonette and Rosenberg's1 report indicates that there is "no single or simple therapeutic agent to be regularly effective for a quick cure." The authors note that this clinical problem has not received substantial attention in the dermatologic literature. Tomoka et al2 note among other factors that bacteriostatic substances inhibiting the dominant Gram-positive microflora can lead to replacement by Gram-negative microflora, namely Pseudomonas. They observe that there are no organisms within the skin, histopathologic findings of a toxic reaction, and that local application of a dilute solution of chloramphenicol prevented dermatitis in four of five subjects. This suggests that a broad spectrum locally applied microbicide would be useful therapy. Glutaraldehyde is bactericidal, tuberculocidal, fungicidal, sporicidal, and viricidal,

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