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February 1974

Tretinoin Treatment of Leg Ulcers

Arch Dermatol. 1974;109(2):262. doi:10.1001/archderm.1974.01630020070022

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To the Editor.—  A paper by Prutkin (Acta Derm Venereol 52:489, 1972) on the stimulating effect of topically applied tretinoin on wound healing in mice and humans led us to try an ointment containing 3% tretinoin in petrolatum on seven hospitalized patients with leg ulcers. These patients, four men and three women, were between 54 and 85 years of age; four had impaired arterial circulation; the impaired circulation was associated with diabetes in one patient, while another patient suffered from extensive deep venous thrombosis. The lesions were traumatic or spontaneous, and measured between 1 and 7 cm.The ointment was applied to the ulcers twice daily. There was no clinically visible effect for the first ten days; after that, exudation of the neighboring skin was seen in all but one case. The dimensions of the ulcers remained unchanged and even increased in two cases. The application was abandoned after

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