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February 1974

Gold Treatment of Pemphigus

Author Affiliations

Charlottesville, Va

Arch Dermatol. 1974;109(2):262-263. doi:10.1001/archderm.1974.01630020070025

To the Editor.—  The rediscovery and demonstration of the therapeutic effectiveness of intramuscularly administered gold in the treatment of pemphigus, as reported in the July Archives (108:56,1973) by Penneys et al,1,2 is important and possibly life-saving, as demonstrated by the following report.

Report of a Case  A 56-year-old white woman developed ocular and oral "irritation" in the fall of 1970. A biopsy specimen of an oral lesion in the late spring of 1971 was interpreted as being compatible with benign mucosal pemphigoid and treatment with 40 mg of prednisone daily was started. The dosage was gradually increased to 120 mg daily over the next four months because of progression of the oral lesions and the development of cutaneous bullae. Another biopsy specimen, in September 1971, this time of a cutaneous bleb, with immunofluorescent studies, revealed that the patient actually had pemphigus vulgaris. Her serum anti-epithelial antibody titer (AEA)

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