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February 1974

Persistent Phototoxicity Due To Nalidixic Acid

Author Affiliations

St. Peters, South Australia

Arch Dermatol. 1974;109(2):263. doi:10.1001/archderm.1974.01630020071026

To the Editor.—  Persistent phototoxicity from demeclocycline, a tetracycline compound, may last for a few weeks or for as long as 22 months.1 Demeclocycline phototoxicity appears as an exaggerated sunburn erythema, whereas nalidixic acid phototoxicity, which shows characteristically as isolated blistering of exposed areas that may or may not be accompanied by erythema, can resemble porphyria cutanea tarda.2,3 Persistent phototoxicity from nalidixic acid is known to occur,3 and I wish to record another case.

Report of a Case  A 2-year-old girl was treated for a urinary infection with 250 mg of nalidixic acid (Negram) three times daily for 17 days during early December, which is a summer month in Australia. The administration of nalidixic acid was discontinued following phototoxic blistering and erythema of the face and the backs of the fingers and hands that healed in ten days, leaving increased freckling and pigmentation. The child was