To the Editor.—
Recent enthusiasm concerning a morphologically unusual cell in the skin of patients with mycosis fungoides (MF) and in skin and blood of patients with the Sézary syndrome1-3 has been tempered by reports that the cell may not be a specific marker for these diseases.4 Electron microscopy shows that the cell of interest has a highly convoluted, serpentine nucleus, resulting in a large increase in the nuclear-cytoplasmic interface. The nuclear characteristics can also be appreciated with the light microscope in well-prepared specimens of tissue and blood. The unusual cell has been found in inflammatory infiltrates associated with several nonlymphomatous dermatoses (such as psoriasis, lichen planus, and discoid lupus erythematosus) and in infiltrates associated with solar keratoses and basal cell carcinoma.4 Blood cells characteristic of Sézary syndrome have an abnormal karyotype and may be derived from the thymus.5,6 However, it has not yet been determined
Sézary-Like Cells in Cultures of Normal Human Skin. Arch Dermatol. 1974;109(4):577–578. doi:10.1001/archderm.1974.01630040081037
Customize your JAMA Network experience by selecting one or more topics from the list below.