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April 1974


Arch Dermatol. 1974;109(4):587. doi:10.1001/archderm.1974.01630040087044

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Stevens-Johnson Syndrome, ?Autoimmune Progesterone Dermatitis. Presented by Anthony N. Domonkos, MD.  A 25-year-old married white woman had a recurrent vesicular eruption involving the oral mucous membranes and arms for the past four years. The condition appeared after the birth of the first child. New crops of blisters appeared at two- to three-week intervals, with clearing of the lesions during the menses. She has been treated in the past with oral administration of prednisone and tetracycline. She also received therapy with a mixture of norgestrel and ethinyl estradiol (Ovral), which was of no benefit.Examination revealed numerous large eroded blisters of the buccal and gingival mucosa. Crusted eroded lesions were evident on the soft and hard palate and on the lips. Large, flaccid bullae and crusted lesions were present on the left elbow, hands, and palms.Since April 9, she has received biweekly injections of 40 units of corticotropin (ACTH) and

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