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June 1974

Topically Active Corticosteroids: A Quantitative Evaluation of McKenzie's Skin-Blanching Test

Author Affiliations

Haarlem, The Netherlands

From Gist-Brocades NV, Research and Development, Haarlem, The Netherlands. Dr. van Wijk is now with the Central Organization for Applied Research in the Netherlands, TNO, The Hague.

Arch Dermatol. 1974;109(6):863-865. doi:10.1001/archderm.1974.01630060041010

This study investigated whether the skin-blanching test designed by McKenzie for screening topically active corticosteroids produces results that are sufficiently quantitative to be used in structure activity relationship investigations.

To this purpose a series of hydrocortisone-17 esters were tested on the healthy human skin of a number of volunteers. The results were expressed by means of two parameters: one that could be measured directly, the spot diameter, and one that was visually evaluated, the blanching score. These two parameters were mutually compaired by regression analysis. The conclusion is that both biological parameters are suited for structure activity relationship studies. A correlation (r=0.972 and 0.988 respectively) between the test results is expressed in either of these parameters.

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