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June 1974

IgG and Complement-Fixing Pseudointercellular Antibodies After Thermal Injury

Author Affiliations

Chicago; Cincinnati

From the Cook County Hospital and Graduate School of Medicine, the Hektoen Institute and the Chicago Medical School University of Health Sciences, Chicago (Dr. Ablin), and the University of Cincinnati College of Medicine and the Shriners Burn Institute, Cincinnati (Dr. Holder).

Arch Dermatol. 1974;109(6):887-888. doi:10.1001/archderm.1974.01630060063018

The IgG and complement-fixing (C'F) peripheral or membranal antinuclear autoantibodies masquerading as intercellular antibodies have been observed by indirect immunofluorescence on autologous skin biopsy specimens of two patients following thermal injury. Immunohistologic localization in these patients of in vivo bound C' to the nuclear membrane, the same site at which in vitro reactions of both IgG and C'F autoantibody occur offer further evidence suggestive of the participation of immunologic phenomena following thermal injury that may contribute to the generalized depression of host resistance in burn patients.

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