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June 1974

Antiepithelial Antibodies: A Possible Clue to Malignant Neoplasms

Arch Dermatol. 1974;109(6):911-912. doi:10.1001/archderm.1974.01630060079027

To the Editor.—  As very appropriately reiterated by Dr. Bystryn and his colleagues,1 the presence of antibodies reactive with components of epithelial tissue has become a wellrecognized phenomenon of considerable diagnostic and prognostic importance in various dermatoses. With reference to their report1 of the presence of antibodies against antigens in the cytoplasm of epidermal cells, particularly in patients with malignant tumors, I should like to communnicate the results of some of my immunofluorescent (IF) studies of patients with benign and malignant diseases of the prostate.I have done studies directed toward defining the possible tissue and disease specificity of antibodies to the cytoplasmic membrane or intercellular (IC) areas of prostatic secretory epithelial cells in patients with benign prostatic hypertrophy and carcinoma of the prostate.2 In these patients, I have observed antibodies reactive with components of stratified squamous epithelium.3,4 These studies, by virtue of the IF staining

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