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June 1974

Antiepithelial Antibodies: A Possible Clue to Malignant Neoplasms-Reply

Arch Dermatol. 1974;109(6):912. doi:10.1001/archderm.1974.01630060080028

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To the Editor.—  We agree with Dr. Ablin that the greater than normal occurrence of antibodies to normal skin antigens in person with malignant neoplasms supports, but does not prove, the concept that some of the cutaneous dermatoses associated with internal malignant neoplasms may be manifestations of immune reactions.We do not believe that the specific staining of cytoplasmic antigens, which we ascribed to anticytoplasmic antibodies, represents a false-positive reaction to antinuclear antibody (ANA) or blood group antigens. None of the sera we tested was positive for ANA. Blood group antigens are localized on cell surfaces and give an intercellular staining pattern when reacting with specific antibody.

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