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June 1974

Transient Acantholytic Dermatosis

Author Affiliations


Arch Dermatol. 1974;109(6):913. doi:10.1001/archderm.1974.01630060081033

To the Editor.—  In 1970, Grover described a peculiar papulovesicular dermatosis which histologically resembled Hailey-Hailey disease or Darier disease (Arch Dermatol 101:426, 1970). The primary lesions were pruritic, discrete papules or vesiculopapules that usually occurred on the trunk but were occasionally present on the extremities. The six patients described by Grover ranged in age from 46 to 74 years and all were white. The eruption was self-limiting and lasted from several weeks to five months, without recurrence. It was stressed that cytologic examination of the vesicles revealed acantholytic cells. The term "transient acantholytic dermatosis" was applied to this clinical entity.We have recently seen what appears to be the first case of this disease in a black person. The patient was a 66-year-old black woman who had a similar clinical and histological picture as that described above. Discrete 1-3 mm pruritic, papulovesicles, with surrounding erythema, were localized on her trunk

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